I might be running a playtest campaign of La Familia soon. As Anna pointed out in our first get-together tonight, LF could totally work as an early-19th-century Cosa Nostra game, set in Sicily.
But that's not the coolest part: a mob game set in Sicily in the 1920's, where Benito fucking Mussolini is the Tyrant (quick recap: the players play members of powerful families; the gm plays a central authority figure in society, called the Tyrant). It would be RAD to play Mussolini.
One of Anna's suggestions was to blur the distinction between the gm and the other players, such that it's not a really "gm'ed" game anymore. I think the easy way to do this is to call one player the Tyrant, give him the power to set Laws, and make his protagonist the Tyrant of the setting. Easy peasy. The word "gm" is incorrect, anyway - the only diff between the Tyrant and the other players is that the Tyrant creates Laws.
Given that you could basically run The Godfather using LF, Anna also pointed out that I should consider putting specific kinds of scenes into the rules - some kinds include Betrayal (maybe a scene in which a Grudge's rating is increased), Retribution (taking revenge for the increased Grudge), and Placation (smoothing over the source of the increased Grudge).
I'll give it some thought.